α-Ketoglutaric acid disodium salt CAS:305-72-6

α-Ketoglutaric acid disodium salt, or sodium α-ketoglutarate, is a key metabolite in cellular respiration and the tricarboxylic acid (TCA) cycle. This compound consists of two sodium ions balanced with the negatively charged α-ketoglutarate anion, providing enhanced solubility and bioavailability compared to its parent acid. With the molecular formula C₅H₆Na₂O₄, sodium α-ketoglutarate serves multiple biological functions and has garnered attention for its potential health benefits. One notable application of sodium α-ketoglutarate is in sports nutrition and dietary supplementation. It is often marketed to athletes and bodybuilders for its purported ability to support muscle recovery, improve exercise performance, and enhance overall energy levels. The compound plays a crucial role in amino acid metabolism by facilitating the transamination process, thereby contributing to protein synthesis and nitrogen balance in the body. Through these mechanisms, sodium α-ketoglutarate may help reduce muscle breakdown and promote muscle growth, making it an attractive supplement for those engaged in rigorous physical activities. In addition to its applications in sports nutrition, sodium α-ketoglutarate has been investigated for its potential therapeutic effects. Research suggests that it may play a role in improving metabolic health, reducing oxidative stress, and supporting mitochondrial function. Some studies have indicated that supplementation with sodium α-ketoglutarate may benefit individuals with certain medical conditions, such as chronic kidney disease, where it could help regulate nitrogen levels. Moreover, sodium α-ketoglutarate is also employed in the food industry as a flavor enhancer and preservative due to its safety profile. Its use as a food additive aligns with its Generally Recognized As Safe (GRAS) status. In summary, α-ketoglutaric acid disodium salt is an important compound in biochemistry and nutrition, with diverse applications in dietary supplementation, therapeutic interventions, and food processing. Understanding its metabolic roles and physiological benefits can facilitate its effective use in health and wellness, paving the way for further research into its potential advantages in various fields.