γ-L-Glutamyl-3-carboxy-4-nitroanilide, monoammonium salt CAS:63699-78-5

γ-L-Glutamyl-3-carboxy-4-nitroanilide, monoammonium salt is a substrate commonly used in biochemical assays to detect and measure the activity of the enzyme γ-glutamyl transpeptidase (GGT). GGT is an enzyme found in various tissues, including the liver, kidneys, and pancreas. It is involved in the breakdown and metabolism of glutathione, an important antioxidant in cells.

The compound is converted by GGT into a yellow-colored product, which can be quantified spectrophotometrically at a specific wavelength. The intensity of the color is directly proportional to the GGT activity in the sample. This allows for the measurement of GGT activity levels, which can help in assessing liver function and diagnosing liver diseases.

The application of γ-L-Glutamyl-3-carboxy-4-nitroanilide, monoammonium salt in GGT assays is useful in various contexts, including clinical diagnostics, research studies, and drug development. It enables the monitoring of GGT activity in patient samples, contributing to the identification and evaluation of liver diseases such as alcoholic liver disease, liver cancers, and drug-induced liver damage.