1,1′-Thiocarbonyldiimidazole CAS:6160-65-2

1,1'-Thiocarbonyldiimidazole acts as a condensing agent, promoting the coupling of amino acid residues to form peptide chains. Its ability to activate carboxylic acids and promote nucleophilic attack by amino groups enables the stepwise assembly of peptides with high yields and minimal side reactions. This compound is particularly useful in solid-phase peptide synthesis and solution-phase peptide coupling reactions, allowing for the rapid and efficient production of a wide range of peptide structures. Moreover, 1,1'-Thiocarbonyldiimidazole finds applications in bioconjugation chemistry, where it is employed for the site-selective modification of biomolecules and the conjugation of peptides to various functional groups or biomolecular targets. Its versatility and compatibility with a variety of substrates make it a valuable tool in the development of peptide-based probes, imaging agents, and therapeutics for biomedical research and drug discovery. Overall, 1,1'-Thiocarbonyldiimidazole plays a crucial role in peptide chemistry and bioconjugation applications, enabling precise control over peptide bond formation and facilitating the synthesis of diverse peptide structures with tailored functionalities. Its efficiency, versatility, and reliability make it a key reagent in the toolbox of researchers and chemists involved in peptide synthesis and bioconjugation studies.