(1R,2S)-2-(4-Chloro-phenyl)-cyclopropylamine hydrochloride CAS:2719682-89-8 209738-22-7

(1R,2S)-2-(4-Chloro-phenyl)-cyclopropylamine hydrochloride has several important applications in organic synthesis and medicinal chemistry. Here are some common uses of this compound: Medicinal Chemistry: The compound serves as a valuable building block for the synthesis of biologically active molecules. It can be utilized in the development of potential drugs targeting various therapeutic areas such as central nervous system disorders, depression, or anxiety. Cyclopropylamine Derivatives: (1R,2S)-2-(4-Chloro-phenyl)-cyclopropylamine hydrochloride can be used as a starting material to synthesize other cyclopropylamine derivatives. Cyclopropylamines possess unique structural features and exhibit diverse biological activities, making them attractive targets for drug discovery. Aromatic Amine Reactions: The presence of the 4-chlorophenyl group allows for various reactions, such as nucleophilic substitution or condensation, to introduce different functional groups or modify the compound's properties. Pharmacological Studies: (1R,2S)-2-(4-Chloro-phenyl)-cyclopropylamine hydrochloride can be used in pharmacological studies to investigate its biological activity or evaluate its potential as a lead compound. It can be screened against various targets to assess its effects and mechanisms of action. Chemical Biology: The compound finds utility in chemical biology studies aiming to investigate biological processes and identify targets for therapeutic intervention. Its incorporation into small molecules enables the exploration of specific cellular pathways or interactions. Heterocycle Synthesis: The compound can undergo reactions to form heterocyclic derivatives, which are core structures found in many biologically active compounds. These heterocyclic derivatives can have diverse pharmacological properties and find applications in drug discovery. Selective Serotonin Reuptake Inhibitors (SSRIs): The cyclopropylamine functionality in this compound makes it suitable for the synthesis of selective serotonin reuptake inhibitors (SSRIs), a class of antidepressant medications. Modifications to the cyclopropylamine moiety can enhance selectivity and potency towards serotonin transporters. Lead Optimization: (1R,2S)-2-(4-Chloro-phenyl)-cyclopropylamine hydrochloride can serve as a starting point for lead optimization through structure-activity relationship studies. Modifications to the 4-chlorophenyl group or cyclopropylamine scaffold can be explored to enhance potency, selectivity, or other pharmacokinetic properties of potential drug candidates. In summary, (1R,2S)-2-(4-Chloro-phenyl)-cyclopropylamine hydrochloride is a versatile compound with various applications in organic synthesis and medicinal chemistry. It plays a critical role in medicinal chemistry, cyclopropylamine derivatives, aromatic amine reactions, pharmacological studies, chemical biology, heterocycle synthesis, SSRIs synthesis, and lead optimization. The compound's high purity, stability, and ability to modify molecules make it valuable in the development of biologically active compounds and the exploration of biological mechanisms.