(1S,2S)-ethyl 2-(4-fluorophenyl)cyclopropanecarboxylate CAS:345891-24-9

As a versatile building block, this enantiopure ester facilitates efficient organic synthesis. Ring-opening reactions on the cyclopropane furnish hydroxy acid/alcohol precursors. These transformations systematically introduce functional diversity for biological screening. Additionally, nucleophilic substitutions on the fluorine furnish analog libraries. The ring-opened products generated lend themselves to further derivatization. Meanwhile, hydrolysis of the ester followed by additional manipulations produces focused collections for drug discovery. This synthon also enables development of optically pure specialty polymers, coatings and liquid crystals. Therefore, with multiple points of reactivity and an integral stereocenter, this versatile building block supports enantioselective synthesis of pharmaceuticals, functional materials and complex molecules through strategic diversification of reactive sites.