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2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate CAS:125700-67-6

2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, commonly known as HBTU, is a chemical compound widely used as a coupling reagent in peptide synthesis and other amide bond-forming reactions. This heterocyclic compound plays a crucial role in organic synthesis, particularly in the field of peptide chemistry, due to its ability to activate carboxylic acids and form highly reactive acylating intermediates, thereby facilitating efficient and selective amide bond formation.


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Application and Effect:

In peptide synthesis, HBTU is utilized for the coupling of amino acids to form peptide bonds with high yields and minimal racemization, making it an essential tool in the production of peptides and peptidomimetics for research, pharmaceutical, and biotechnological applications. Its usage ensures the preservation of stereochemistry and overall efficiency in the synthesis of complex peptide sequences. Moreover, HBTU finds application in the preparation of active pharmaceutical ingredients (APIs) and drug conjugates, contributing to its significance in medicinal chemistry and drug discovery. The compound's unique reactivity and reagent properties enable the synthesis of pharmaceutical compounds with improved pharmacokinetic and pharmacodynamic profiles, making it valuable in the development of novel drugs and therapeutic agents. Additionally, HBTU has been employed in materials science as a reagent for the modification of surfaces and the synthesis of functional materials. Its capacity to form stable intermediates and its compatibility with various substrates make it valuable in surface functionalization and the creation of bioconjugates, which are relevant in the development of advanced materials for biomedical and biotechnological applications. In summary, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (HBTU) is a versatile compound with significant applications in organic synthesis, medicinal chemistry, and material science. Its pivotal role as a coupling reagent in peptide synthesis, along with its relevance in drug discovery and materials modification, underscores its importance in diverse scientific and industrial fields. Continued research and utilization of HBTU continue to drive advancements in peptide chemistry, pharmaceutical synthesis, and material engineering, further solidifying its status as a valuable and multifaceted chemical reagent.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C11H16BF4N5O
Assay 99%
Appearance white powder
CAS No.  125700-67-6
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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