2-Bromo-5-hydroxypyridine CAS:55717-45-8

2-Bromo-5-hydroxypyridine is a notable organic compound characterized by the molecular formula C5H5BrN2O. Its structure consists of a pyridine ring that contains a bromine atom at the 2-position and a hydroxyl group (-OH) at the 5-position. This distinct substitution pattern imparts unique electronic and steric properties, which enhance the compound's utility in various chemical reactions and synthetic applications. The bromine atom in 2-bromo-5-hydroxypyridine serves as a potent electrophile, enabling the compound to undergo various nucleophilic substitution reactions. In particular, the halogen can be replaced by nucleophiles, allowing for the generation of diverse derivatives suited for multiple applications. Meanwhile, the hydroxyl group contributes to the compound's ability to form hydrogen bonds, significantly influencing its solubility and interaction with other molecules. These characteristics make 2-bromo-5-hydroxypyridine an important building block in organic synthesis. In medicinal chemistry, derivatives of 2-bromo-5-hydroxypyridine have attracted considerable interest due to their potential biological activities. Research has indicated that such derivatives may exhibit antimicrobial, antiviral, or anticancer effects. By exploring the structure-activity relationships (SAR) associated with these compounds, researchers aim to develop new therapeutic agents that target specific biological pathways. Beyond its role in drug discovery, 2-bromo-5-hydroxypyridine is also relevant in materials science. The ability to functionalize this compound opens avenues for creating specialized materials, including polymers and coatings with unique properties. In conclusion, 2-bromo-5-hydroxypyridine exemplifies the importance of halogenated pyridine derivatives in contemporary organic chemistry. Its unique reactivity and potential for fostering biological activity continue to stimulate research aimed at discovering innovative compounds, ultimately contributing to advancements in both pharmaceuticals and material science.