2-CHLORO-3-FLUORO-4-FORMYLPYRIDINE CAS:329794-28-7

2-Chloro-3-fluoro-4-formylpyridine is a notable organic compound characterized by the molecular formula C6H4ClFNO. Its structure consists of a pyridine ring that has three important substituents: a chlorine atom at the 2-position, a fluorine atom at the 3-position, and a formyl group (-CHO) at the 4-position. This specific arrangement of functional groups confers unique electronic and steric properties, making it a significant compound in organic synthesis and medicinal chemistry. The chlorination and fluorination of the pyridine ring dramatically influence the compound's reactivity. The chlorine atom enhances electrophilicity, facilitating nucleophilic substitution reactions, while the fluorine atom contributes to the overall stability of intermediates through strong electronegative interactions. The formyl group, being a reactive aldehyde, can participate in various chemical reactions, including condensation, oxidation, and addition reactions. This versatility allows 2-chloro-3-fluoro-4-formylpyridine to serve as a crucial building block for synthesizing more complex structures. In the realm of medicinal chemistry, derivatives of 2-chloro-3-fluoro-4-formylpyridine have garnered interest due to their potential biological activities. Research indicates that these compounds may exhibit antimicrobial, anti-inflammatory, or anticancer properties, making them candidates for drug development. The exploration of structure-activity relationships (SAR) related to this compound can lead to the identification of novel therapeutic agents. Furthermore, 2-chloro-3-fluoro-4-formylpyridine has applications beyond pharmaceuticals. Its reactivity enables the production of specialized materials, including polymers and fine chemicals, which can be used in various industrial processes. In summary, 2-chloro-3-fluoro-4-formylpyridine exemplifies the utility of halogenated pyridine derivatives in modern organic chemistry. Its unique combination of reactivity and potential biological activity continues to drive research aimed at discovering innovative compounds, thereby contributing to advancements in drug discovery and material science.