2-(Ethoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid CAS:132589-66-3

2-(Ethoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid can act as a essential building block in organic synthesis. The ethyl ester and acid groups expand the synthetic handleability and functional diversity that can be attained. The ester allows for mild alkylation/acylation of the amide nitrogen. Hydrolysis of the ester produces the valuable diacid. Meanwhile, reactions on the aromatic ring can give rise to substituted tetrahydroisoquinoline derivatives with therapeutic properties. The acid group is also susceptible to coupling chemistry for C-N bond formation. This produces pharmaceutically active quinoline alkaloids or aids in the assembly of natural product analogues. Overall, due to the combined reactivity of its functional components, this tetrahydroisoquinoline carboxylic ester serves as an indispensable synthon in synthesizing agrochemicals, pharmaceuticals and functional materials.