2-Hydroxy-5-bromopyridine CAS:13466-38-1

The synthesis of 2-Hydroxy-5-bromopyridine typically involves synthetic routes utilizing commercially available starting materials. Common methods may include the bromination of 2-hydroxypyridine to introduce the bromine atom at the 5-position. Analytical techniques such as NMR, IR, and mass spectrometry are employed to validate the compound's structure and purity. Molecularly, 2-Hydroxy-5-bromopyridine comprises a pyridine ring substituted with a hydroxyl group at the 2-position and a bromine atom at the 5-position. This molecular arrangement offers opportunities for further chemical modifications and interactions with biological targets. Pharmacological Significance and Potential Applications The structural attributes of 2-Hydroxy-5-bromopyridine make it a promising candidate for pharmaceutical research. Pyridine derivatives have been explored for various pharmacological activities, including antimicrobial, anti-inflammatory, and antitumor properties. The presence of the hydroxyl group may contribute to the compound's biological activity through hydrogen bonding and potential interactions with biological targets. 2-Hydroxy-5-bromopyridine may serve as a scaffold for the development of drug candidates targeting infectious diseases, inflammatory disorders, and cancer. Additionally, the bromine atom may influence the compound's pharmacokinetics and biological activity, potentially enhancing its therapeutic efficacy. In conclusion, 2-Hydroxy-5-bromopyridine presents a unique molecular scaffold with significant pharmaceutical implications. Further exploration into its synthesis, pharmacology, and medicinal chemistry is imperative to fully harness its therapeutic potential and applications in drug discovery and development.