2-Iodobenzoic acid CAS:88-67-5

2-Iodobenzoic acid (C7H5IO2) is an organic compound belonging to the class of benzoic acids, distinguished by the substitution of an iodine atom at the 2-position of the benzene ring. This structural arrangement imparts unique chemical properties, allowing it to participate in diverse chemical reactions. Its functional groups—a carboxylic acid (-COOH) and an iodine substituent—significantly influence its reactivity and solubility characteristics. The iodine atom is a potent electron-withdrawing group, which increases the acidity of the carboxylic acid. This heightened acidity can be leveraged in various synthetic pathways, making 2-iodobenzoic acid a useful building block in organic synthesis. It serves as a precursor in the preparation of numerous pharmaceuticals, agrochemicals, and fine chemicals. One notable application of 2-iodobenzoic acid is in cross-coupling reactions, particularly the Suzuki-Miyaura coupling, where it acts as an electrophile to form C–C bonds. This method is invaluable in constructing complex organic molecules with precision and efficiency. Additionally, it can be used in nucleophilic aromatic substitution reactions, where its ability to stabilize negative charges through resonance plays a critical role. Moreover, its derivatives are investigated for potential biological activities, including antimicrobial and anti-inflammatory properties. Research into 2-iodobenzoic acid continues to expand, particularly concerning its roles in creating new materials and studying molecular interactions. As such, this compound stands out not only for its utility in synthetic organic chemistry but also for its contributions to advancing material sciences and medicinal research.