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2-Methoxy-5-fluorouracil CAS:1480-96-2

2-Methoxy-5-fluorouracil is a fluorinated pyrimidine derivative of uracil, characterized by the presence of a methoxy group at the 2-position and a fluorine atom at the 5-position. This compound has drawn significant interest in medicinal chemistry due to its potential as an antitumor agent. Its structural modifications allow it to enhance the efficacy of traditional chemotherapy while potentially reducing side effects associated with conventional treatments.

 


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Application and Effect:

2-Methoxy-5-fluorouracil has several applications primarily in the field of cancer treatment. As a derivative of 5-fluorouracil (5-FU), a well-known chemotherapeutic agent, it retains the ability to interfere with nucleic acid synthesis. The methoxy substitution enhances its pharmacokinetic properties, such as solubility and cellular uptake, which can lead to improved therapeutic outcomes. Researchers are investigating its use not only as a standalone treatment but also in combination therapies aimed at increasing the efficacy of existing cancer drugs. The mechanism of action for 2-methoxy-5-fluorouracil involves its conversion into active metabolites that inhibit thymidylate synthase, an enzyme critical for DNA synthesis and repair. By disrupting DNA replication in rapidly dividing cancer cells, this compound may induce cell death and slow tumor growth. Studies suggest that the methoxy group may contribute to increased selectivity toward cancer cells, potentially leading to reduced toxicity in normal tissues. In addition to its application in oncology, 2-methoxy-5-fluorouracil is also being explored for its role in targeted therapy. Its ability to modify metabolic pathways makes it a candidate for research into personalized medicine, where treatments are tailored based on individual patient profiles. The compound could be utilized to overcome resistance mechanisms commonly seen in tumors treated with standard 5-FU. Furthermore, ongoing studies are evaluating its potential in treating other diseases where abnormal cell proliferation is a factor, such as certain autoimmune disorders. The versatility of 2-methoxy-5-fluorouracil reflects its promise as a valuable agent in both cancer therapy and broader biomedical research. Overall, 2-methoxy-5-fluorouracil represents a significant advancement in the development of fluoropyrimidine-based therapeutics, showcasing its potential to enhance cancer treatment strategies and improve patient outcomes.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C5H5FN2O2
Assay 99%
Appearance white powder
CAS No.  1480-96-2
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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