2-Phenoxyethyl chloroformate CAS:34743-87-8
2-Phenoxyethyl chloroformate (C10H11ClO3) is a versatile reagent used extensively in organic chemistry, particularly in the synthesis of esters and carbamates. The compound consists of a 2-phenoxyethyl group linked to a chloroformate functional group, which significantly enhances its electrophilic character. This property allows it to readily undergo nucleophilic acyl substitution reactions, reacting efficiently with various alcohols and amines to form corresponding acyl derivatives. One of the primary applications of 2-phenoxyethyl chloroformate is in the synthesis of esters. By reacting with alcohols, it yields phenoxyethyl esters that are valuable in numerous industries, including pharmaceuticals, cosmetics, and food. The introduction of the phenoxy group can enhance the stability and reactivity of these esters, making them suitable for diverse applications. In addition to ester synthesis, 2-phenoxyethyl chloroformate is utilized in the production of carbamates. These compounds serve as important intermediates in drug synthesis and agricultural chemicals, where they often exhibit biological activity. The incorporation of the phenoxyethyl moiety can influence the pharmacokinetics and therapeutic profile of potential drug candidates. Furthermore, 2-phenoxyethyl chloroformate functions as a protecting group for alcohols and amines during multi-step organic syntheses. By temporarily modifying these reactive sites, chemists can control reaction pathways more effectively, allowing for selective transformations. The ease of removal of the protecting group under mild conditions makes this reagent particularly attractive. Despite its utility, handling 2-phenoxyethyl chloroformate requires caution due to its irritant properties and potential toxicity. Safety protocols, such as wearing protective equipment and working within well-ventilated areas, are essential when employing this reagent. In summary, 2-phenoxyethyl chloroformate is a key reagent in organic synthesis, enabling the development of complex molecules in pharmaceuticals, agrochemicals, and materials science. Its versatility and reactivity make it invaluable for contemporary chemical research and application.
Composition | C9H9ClO3 |
Assay | 99% |
Appearance | white powder |
CAS No. | 34743-87-8 |
Packing | Small and bulk |
Shelf Life | 2 years |
Storage | Store in cool and dry area |
Certification | ISO. |