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2-Phenoxyethyl chloroformate CAS:34743-87-8

2-Phenoxyethyl chloroformate is a notable organic compound characterized by the presence of a phenoxy group attached to a chloroformate functional group. This reagent serves primarily as an acylating agent in organic synthesis, facilitating the formation of esters and carbamates through nucleophilic substitution reactions with alcohols and amines. The phenoxyethyl moiety imparts unique properties that can modify the solubility and reactivity of target compounds. Its applications are widespread in pharmaceutical development, agrochemicals, and materials science, making it an essential tool for chemists looking to create complex organic structures. Understanding its reactivity is crucial for effective utilization in synthetic pathways.


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Application and Effect:

2-Phenoxyethyl chloroformate (C10H11ClO3) is a versatile reagent used extensively in organic chemistry, particularly in the synthesis of esters and carbamates. The compound consists of a 2-phenoxyethyl group linked to a chloroformate functional group, which significantly enhances its electrophilic character. This property allows it to readily undergo nucleophilic acyl substitution reactions, reacting efficiently with various alcohols and amines to form corresponding acyl derivatives. One of the primary applications of 2-phenoxyethyl chloroformate is in the synthesis of esters. By reacting with alcohols, it yields phenoxyethyl esters that are valuable in numerous industries, including pharmaceuticals, cosmetics, and food. The introduction of the phenoxy group can enhance the stability and reactivity of these esters, making them suitable for diverse applications. In addition to ester synthesis, 2-phenoxyethyl chloroformate is utilized in the production of carbamates. These compounds serve as important intermediates in drug synthesis and agricultural chemicals, where they often exhibit biological activity. The incorporation of the phenoxyethyl moiety can influence the pharmacokinetics and therapeutic profile of potential drug candidates. Furthermore, 2-phenoxyethyl chloroformate functions as a protecting group for alcohols and amines during multi-step organic syntheses. By temporarily modifying these reactive sites, chemists can control reaction pathways more effectively, allowing for selective transformations. The ease of removal of the protecting group under mild conditions makes this reagent particularly attractive. Despite its utility, handling 2-phenoxyethyl chloroformate requires caution due to its irritant properties and potential toxicity. Safety protocols, such as wearing protective equipment and working within well-ventilated areas, are essential when employing this reagent. In summary, 2-phenoxyethyl chloroformate is a key reagent in organic synthesis, enabling the development of complex molecules in pharmaceuticals, agrochemicals, and materials science. Its versatility and reactivity make it invaluable for contemporary chemical research and application.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C9H9ClO3
Assay 99%
Appearance white powder
CAS No.  34743-87-8
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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