2-tert-butyl 8-methyl 5-amino-3,4-dihydroisoquinoline-2,8(1H)-dicarboxylate CAS:2757925-41-8

This polyfunctional molecule serves as a versatile building block. Reactions at the amino group install diverse alkyl/aryl chains to probe structure-activity relationships. Ester hydrolysis followed by coupling introduces heterogeneity at C2/C8. Decarboxylation furnishes valuable isoquinoline precursors. Such transformation enables development of focused alkaloid and drug libraries. The rigid planar structure also facilitates polymerization, accessing chiral materials. Additionally, natural product analog synthesis routes can be investigated, expanding opportunities for agrochemical and pharmaceutical lead identification. In summary, its elaborate structure coupled with reactivity handles renders this an important synthon.