2(1H)-Quinolinone,4-(bromomethyl)- CAS:4876-10-2

4-(bromomethyl)-2(1H)-quinolinone serves as an important building block in pharmaceutical chemistry. The bromomethyl group allows for amination, resulting in phenothiazine- and acridine-based drugs with antimalarial, antibacterial and antipsychotic properties. It undergoes nucleophilic substitutions with amines, alcohols and thiols under mild conditions to form quinoline-containing compounds. This assists in developing antifungal, anticancer and anticonvulsant agents. As the bromine is easily replaceable, it enables multi-step sequential couplings for complex molecule synthesis. Additionally, 4-(bromomethyl)-2(1H)-quinolinone acts as an intermediate in manufacturing dyes, pigments, agrochemicals and electroactive materials. It also aids research in metal-halide catalysis, heterocyclic chemistry and pharmaceutical sciences.