2,2,2-trifluoro-1-(6-methoxy-1H-indol-3-yl)ethan-1-one CAS:676476-94-1

2,2,2-Trifluoro-1-(6-methoxy-1H-indol-3-yl)ethan-1-one can be used to synthesize various pharmaceutical intermediates and bioactive molecules. The trifluoroacetyl group enhances the reactivity at the alpha carbon position compared to an acetyl group. This makes it highly reactive towards nucleophiles such as amines and alcohols to form amides and esters respectively under mild conditions. The indole ring is an important motif found in many natural products and biologically active compounds. Reactions that functionalize the indole ring can generate pharmaceutically relevant building blocks. Additionally, the trifluoroacetyl group can be removed under basic conditions to give primary alcohols or undergo reductive defluorination to provide ketones. These transformations expand the scope of chemical manipulations possible using this intermediate. In summary, 2,2,2-Trifluoro-1-(6-methoxy-1H-indol-3-yl)ethan-1-one serves as a versatile synthon for the synthesis of valuable drug-like molecules via its chemistry at both the trifluoroacetyl and indole positions.