2′,3′-Di-O-acetyl-5′-deoxy-5-fuluro-D-cytidine CAS:161599-46-8

2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine serves pivotal roles in medicinal chemistry and therapeutic development. As a modified nucleoside derivative, it exhibits selective interactions with cellular enzymes involved in nucleotide metabolism, making it a promising candidate for antiviral therapies. Researchers investigate its efficacy against viral infections such as hepatitis C and HIV, exploring its mechanism of action in inhibiting viral RNA synthesis or integration. In oncology, derivatives of 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine are studied for their potential as chemotherapeutic agents. The fluorine substitution and acetyl groups can enhance cellular uptake and metabolic stability, potentially improving efficacy and reducing cytotoxicity compared to unmodified nucleosides. These modifications aim to selectively target cancer cells by disrupting DNA or RNA synthesis, thereby inhibiting tumor growth while minimizing harm to healthy tissues. Beyond antiviral and anticancer applications, this compound contributes to fundamental research in nucleoside chemistry. Its synthesis and structural modifications provide insights into structure-activity relationships and enzymatic interactions, guiding the design of new nucleoside analogs with optimized pharmacological properties. In pharmaceutical development, 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine serves as a scaffold for creating novel nucleoside-based drugs. Chemists explore its synthetic versatility to produce analogs tailored for specific therapeutic targets or mechanisms of action. This versatility extends its potential applications into areas such as antiparasitic and antibacterial therapies, where nucleoside analogs have shown promise in inhibiting essential metabolic pathways in pathogens. Academically, researchers utilize 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine to advance understanding of nucleoside metabolism and nucleotide analog design. Studies focus on elucidating its biochemical interactions and exploring strategies for overcoming resistance mechanisms that may limit its clinical effectiveness. In summary, 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine represents a versatile tool in nucleoside chemistry and pharmaceutical research. Its applications span from antiviral and anticancer therapies to fundamental studies in nucleoside biochemistry, highlighting its potential impact on therapeutic innovation and scientific discovery.