(2R,4R)-tert-butyl 4-hydroxy-2-(iodomethyl)pyrrolidine-1-carboxylate CAS:132589-66-3

This compound possesses considerable synthetic utility in organic synthesis of pharmaceuticals and agrochemicals. The alcohol group can engage in ether formation, oxidation and esterification reactions. It adds functional diversity under mild conditions. The iodine atom enables carbon-carbon bond forming reactions like cross-couplings. This permits C-C bond construction at the pyrrolidine aliphatic position. Hydrolysis of the ester yields the valuable amino acid. Additionally, the stereochemistry affords an opportunity for asymmetric synthesis. The versatility of this molecule stems from the variety of functional handles and its chiral scaffold. It serves as a key building block for naturally occurring alkaloids and drug-like molecules in general.