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3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENOL CAS:214360-76-6

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, commonly referred to as TMDP, is a chemical compound categorized under phenolic boronic esters. Its molecular structure comprises a phenolic hydroxyl group attached to a phenyl ring bearing a boron-containing cyclic ester moiety with four methyl groups. This compound holds significant importance in organic synthesis, especially in Suzuki-Miyaura cross-coupling reactions, where it serves as a crucial boronic ester reagent. Additionally, its stable cyclic boronate structure and steric hindrance make it valuable in ligand design for transition metal-catalyzed reactions and in the development of functional materials.


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Application and Effect:

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (TMDP) is a versatile compound known for its unique molecular structure and diverse applications across various domains of chemistry. 1. Synthetic Chemistry: Suzuki-Miyaura Cross-Coupling: TMDP serves as a vital boronic ester reagent in Suzuki-Miyaura cross-coupling reactions, facilitating the synthesis of biaryl compounds. This reaction is instrumental in the construction of complex organic molecules in pharmaceutical and materials chemistry. 2. Transition Metal Catalysis: Ligand Design: The boron-containing cyclic ester moiety of TMDP, combined with its steric hindrance from the four methyl groups, makes it an excellent ligand for transition metal-catalyzed reactions. It enhances catalytic activity and selectivity in various transformations, including carbon-carbon and carbon-nitrogen bond formations. 3. Functional Materials: Polymer Engineering: TMDP and its derivatives are incorporated into polymers to confer specific properties such as thermal stability, mechanical strength, and optical activity. These tailored polymers are utilized in diverse applications, including electronics, optoelectronics, and materials science. Surface Modification: TMDP can be immobilized onto surfaces to introduce functional groups for subsequent reactions, such as bioconjugation or chemical sensing, making it valuable in surface chemistry, nanotechnology, and bioengineering. 4. Biomedical Applications: Drug Delivery Systems: TMDP-containing polymers or nanoparticles are employed as carriers for drug delivery, where the boronate ester linkage can undergo controlled cleavage, releasing the encapsulated drug at the desired site. Bioorthogonal Chemistry: TMDP derivatives are utilized in bioorthogonal reactions for labeling biomolecules in live systems, enabling the visualization and interrogation of biological processes with minimal interference. In summary, 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is a versatile compound with wide-ranging applications in synthetic chemistry, catalysis, materials science, and biomedicine. Its distinctive structure and reactivity continue to inspire advancements in these fields, driving innovation and discovery.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C12H17BO3
Assay 99%
Appearance white powder
CAS No.  214360-76-6
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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