4-Bromochlorobenzene CAS:106-39-8
4-Bromochlorobenzene (C₆H₄BrCl) is characterized by its distinct structure featuring a benzene ring with bromine and chlorine substituents positioned at the para locations. The presence of these halogen atoms significantly influences the chemical properties of the compound, including its reactivity in various organic reactions. Typically, 4-bromochlorobenzene is encountered as a clear or slightly yellow liquid with a pleasant aroma. Although it has low water solubility, it dissolves readily in common organic solvents like ether, chloroform, and alcohols. The synthesis of 4-bromochlorobenzene can be accomplished through several methods, primarily involving the bromination of chlorobenzene or the chlorination of bromobenzene using electrophilic aromatic substitution techniques. During these reactions, either bromine or chlorine acts as the electrophile, often facilitated by Lewis acids such as aluminum chloride (AlCl₃) to enhance reaction efficiency. Regioselectivity is vital in these processes, ensuring that the halogens are positioned correctly on the aromatic system. In organic synthesis, 4-bromochlorobenzene serves as a versatile intermediate due to its reactive halogen substituents. It can participate in various nucleophilic substitution reactions, where nucleophiles replace the bromine or chlorine atom, facilitating the creation of a wide range of functionalized compounds. For instance, interactions with amines can yield amine derivatives, while reactions with alcohols can produce ethers, both of which are essential in pharmaceutical synthesis and materials science. Moreover, 4-bromochlorobenzene is employed in the production of specialty chemicals and agrochemicals. Its capacity to engage in cross-coupling reactions—such as Suzuki and Heck reactions—allows chemists to construct complex molecular frameworks that are crucial in drug design and industrial applications. While working with 4-bromochlorobenzene, safety precautions are necessary due to potential health hazards, including irritative effects upon skin and eye contact as well as respiratory risks. Therefore, appropriate personal protective equipment should be used, and all safety protocols must be followed. In summary, 4-bromochlorobenzene is a significant compound within the field of organic chemistry, valued for its reactivity and utility as a precursor in the synthesis of diverse chemical products. Its role in the development of pharmaceuticals, agrochemicals, and specialty chemicals highlights its importance in advancing both research and industrial practices in modern chemistry.
Composition | C6H4BrCl |
Assay | 99% |
Appearance | white powder |
CAS No. | 106-39-8 |
Packing | Small and bulk |
Shelf Life | 2 years |
Storage | Store in cool and dry area |
Certification | ISO. |