4-(Hydroxymethyl)phenylboronic acid CAS:59016-93-2

4-(Hydroxymethyl)phenylboronic acid (4-HMPBA) is a versatile compound with a boronic acid functional group attached to a phenyl ring substituted with a hydroxymethyl group at the para position, endowing it with unique properties and applications. 1. Synthetic Chemistry: Suzuki-Miyaura Cross-Coupling: 4-HMPBA is employed as a key reagent in Suzuki-Miyaura cross-coupling reactions, facilitating the synthesis of biaryl compounds. This reaction is pivotal in organic synthesis, enabling the construction of complex molecules and pharmaceutical intermediates. 2. Sensing and Analytical Chemistry: Diol and Sugar Sensing: Due to its boronic acid functionality, 4-HMPBA exhibits high affinity for diols and sugars. This property is exploited in the development of sensors for glucose monitoring, environmental analysis, and biomedical diagnostics. 3. Medicinal Chemistry: Drug Design: 4-HMPBA and its derivatives are investigated for their potential as enzyme inhibitors and receptor ligands. By modulating enzyme activity or binding to specific receptors, they hold promise in the development of therapeutics for various diseases, including cancer and diabetes. Prodrug Development: The hydroxymethyl group of 4-HMPBA enables prodrug design, where the compound is conjugated to pharmacologically active molecules, facilitating targeted drug delivery and enhanced therapeutic efficacy. 4. Material Science: Functional Materials: 4-HMPBA derivatives are incorporated into polymers and materials to impart specific properties such as adhesion, conductivity, and biocompatibility. These materials find applications in coatings, electronics, and biomedicine. In conclusion, 4-(Hydroxymethyl)phenylboronic acid is a versatile compound with diverse applications spanning synthetic chemistry, sensing, medicinal chemistry, and material science. Its unique structure and reactivity continue to inspire research and innovation in various fields.