4-METHOXYPHENYL CHLOROFORMATE CAS:7693-41-6
4-Methoxyphenyl chloroformate (C9H9ClO3) is a valuable reagent in the field of organic chemistry, particularly known for its role in acylation reactions. The presence of the methoxy group on the aromatic ring increases the electron density at the ortho and para positions, enhancing the electrophilicity of the adjacent chloroformate carbon. This property makes 4-methoxyphenyl chloroformate an effective acylating agent, allowing for rapid and efficient nucleophilic substitution with various nucleophiles, such as alcohols and amines. One of the primary uses of 4-methoxyphenyl chloroformate is in the synthesis of esters. When reacted with alcohols, the compound can yield corresponding esters that often exhibit desirable properties, making them suitable for use in fragrances, cosmetics, and food flavoring. Additionally, when 4-methoxyphenyl chloroformate reacts with amines, it produces carbamates, which are crucial intermediates in the synthesis of pharmaceuticals and agrochemicals. In pharmaceutical research, the ability to introduce the 4-methoxyphenyl moiety into target molecules can significantly enhance their biological activity, selectivity, and solubility. The methoxy group not only modifies the physicochemical properties of the compounds but can also influence their interaction with biological targets. Moreover, 4-methoxyphenyl chloroformate is used as a protecting group for alcohols and amines in complex synthetic routes. It allows for selective deprotection under mild conditions, providing chemists with greater control over reaction pathways and the overall synthesis of multi-functionalized compounds. While utilizing 4-methoxyphenyl chloroformate, careful handling is necessary due to its irritant nature and potential toxicity. Adhering to safety protocols, including working in fume hoods and wearing appropriate protective equipment, is essential. In summary, 4-methoxyphenyl chloroformate is a crucial reagent in organic synthesis, enabling the development of complex molecules in pharmaceuticals, agrochemicals, and materials science, thereby playing a significant role in modern chemical research.
Composition | C8H7ClO3 |
Assay | 99% |
Appearance | white powder |
CAS No. | 7693-41-6 |
Packing | Small and bulk |
Shelf Life | 2 years |
Storage | Store in cool and dry area |
Certification | ISO. |