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4-Nitrobenzyl chloroformate CAS:4457-32-3

4-Nitrobenzyl chloroformate is an important organic compound widely used in synthetic chemistry. This reagent features a 4-nitrobenzyl group attached to a chloroformate moiety, making it valuable for various chemical transformations. The presence of the nitro group enhances the electrophilicity of the carbonyl carbon, facilitating its reactivity with nucleophiles. It finds applications in synthesizing esters, carbonates, and other derivatives, playing a significant role in pharmaceutical and agrochemical development. Understanding its properties and reactions is vital for chemists seeking to leverage this compound in creating complex organic molecules.


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Application and Effect:

4-Nitrobenzyl chloroformate (C8H8ClNO4) is a reactive organic compound that serves as a versatile reagent in synthetic organic chemistry. Its structure consists of a 4-nitrobenzyl group bonded to a chloroformate functional group, which makes it particularly useful for performing acylation reactions. The 4-nitro substitution on the benzene ring increases the electron-withdrawing ability, enhancing the electrophilic character of the carbonyl carbon in the chloroformate group. This property allows it to readily react with various nucleophiles, including alcohols and amines, leading to the formation of esters and carbamates. One of the primary applications of 4-nitrobenzyl chloroformate lies in its use as an acylating agent in the synthesis of pharmaceuticals and advanced materials. The ability to introduce the 4-nitrobenzyl group into target molecules can significantly impact their biological activity and pharmacokinetic properties. For instance, compounds with nitro groups are often found in many biologically active substances, contributing to their therapeutic efficacy. Moreover, 4-nitrobenzyl chloroformate can participate in a variety of synthetic strategies, such as protecting group chemistry, where it temporarily modifies functional groups to prevent unwanted reactions during multi-step syntheses. The ease of removal of the 4-nitrobenzyl group under mild conditions further adds to its utility. Despite its advantages, caution is required when handling 4-nitrobenzyl chloroformate due to its potential toxicity and irritant properties. Proper safety measures, including the use of personal protective equipment and working under a fume hood, are essential. In conclusion, 4-nitrobenzyl chloroformate is a crucial reagent in organic synthesis, enabling chemists to create diverse and complex structures essential for pharmaceutical and material science advancements.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C8H6ClNO4
Assay 99%
Appearance white powder
CAS No.  4457-32-3
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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