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5-Azacytidine CAS:320-67-2

5-Azacytidine is a synthetic nucleoside analogue of cytidine that contains a nitrogen atom in the 5-position of the pyrimidine ring, replacing a carbon atom. This modification imparts unique pharmacological properties, making it an essential compound in molecular biology and cancer therapy. As a potent DNA methyltransferase inhibitor, 5-azacytidine can reactivate silenced genes by altering DNA methylation patterns, thereby influencing gene expression. Originally developed for treating hematologic malignancies, 5-azacytidine has gained attention for its potential applications in epigenetic therapy, regenerative medicine, and research targeting various diseases characterized by abnormal gene regulation.


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Application and Effect:

5-Azacytidine is a cytidine analog distinguished by the substitution of a nitrogen atom for a carbon atom at the 5-position of the pyrimidine ring. This structural alteration allows it to exhibit unique biological activities, particularly as a DNA methyltransferase inhibitor. By inhibiting these enzymes, 5-azacytidine disrupts the normal methylation patterns of DNA, which is crucial for regulating gene expression. This mechanism makes it a valuable tool in cancer treatment, especially for hematological malignancies like myelodysplastic syndromes and acute myeloid leukemia. In cancer cells, aberrant DNA methylation often leads to the silencing of tumor suppressor genes, contributing to uncontrolled cell proliferation. By demethylating DNA, 5-azacytidine can reactivate these silenced genes, providing a therapeutic avenue to reverse some aspects of malignant transformation. Clinical studies have shown that 5-azacytidine can improve survival rates and overall outcomes for patients with certain types of blood cancers, highlighting its potential as a targeted therapy. Beyond its use in oncology, 5-azacytidine is also gaining traction in the field of regenerative medicine. Research indicates that its ability to modulate gene expression may facilitate tissue repair and regeneration by promoting the activation of specific cellular pathways involved in differentiation and growth. Furthermore, 5-azacytidine's role in epigenetics has expanded its application to various research settings, including studies investigating the mechanisms of gene regulation and cellular aging. Its capacity to alter DNA methylation provides insights into the epigenetic landscape of various diseases, paving the way for novel therapeutic strategies. Overall, 5-azacytidine stands out as a significant compound with diverse implications in cancer therapy and regenerative medicine. Its unique mechanism of action underscores the importance of epigenetic regulation in health and disease, offering promising avenues for future research and clinical applications.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C8H12N4O5
Assay 99%
Appearance white powder
CAS No.  320-67-2
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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