5-Azacytidine CAS:320-67-2
5-Azacytidine is a cytidine analog distinguished by the substitution of a nitrogen atom for a carbon atom at the 5-position of the pyrimidine ring. This structural alteration allows it to exhibit unique biological activities, particularly as a DNA methyltransferase inhibitor. By inhibiting these enzymes, 5-azacytidine disrupts the normal methylation patterns of DNA, which is crucial for regulating gene expression. This mechanism makes it a valuable tool in cancer treatment, especially for hematological malignancies like myelodysplastic syndromes and acute myeloid leukemia. In cancer cells, aberrant DNA methylation often leads to the silencing of tumor suppressor genes, contributing to uncontrolled cell proliferation. By demethylating DNA, 5-azacytidine can reactivate these silenced genes, providing a therapeutic avenue to reverse some aspects of malignant transformation. Clinical studies have shown that 5-azacytidine can improve survival rates and overall outcomes for patients with certain types of blood cancers, highlighting its potential as a targeted therapy. Beyond its use in oncology, 5-azacytidine is also gaining traction in the field of regenerative medicine. Research indicates that its ability to modulate gene expression may facilitate tissue repair and regeneration by promoting the activation of specific cellular pathways involved in differentiation and growth. Furthermore, 5-azacytidine's role in epigenetics has expanded its application to various research settings, including studies investigating the mechanisms of gene regulation and cellular aging. Its capacity to alter DNA methylation provides insights into the epigenetic landscape of various diseases, paving the way for novel therapeutic strategies. Overall, 5-azacytidine stands out as a significant compound with diverse implications in cancer therapy and regenerative medicine. Its unique mechanism of action underscores the importance of epigenetic regulation in health and disease, offering promising avenues for future research and clinical applications.
Composition | C8H12N4O5 |
Assay | 99% |
Appearance | white powder |
CAS No. | 320-67-2 |
Packing | Small and bulk |
Shelf Life | 2 years |
Storage | Store in cool and dry area |
Certification | ISO. |