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5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine CAS:799842-07-2

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine is a complex organic compound that plays a crucial role as a synthetic intermediate in the pharmaceutical industry. Its structure consists of a pyrimidine core, a five-membered aromatic ring with nitrogen atoms at positions 1, 3, and 5, which is a common structural feature in many biologically active compounds.


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Application and Effect:

The pyrimidine ring is substituted at the 4-position with a 4-fluorophenyl group, an aromatic group that introduces a strong electron-withdrawing effect due to the presence of fluorine. This substitution can influence the chemical reactivity of the compound and its interactions with biological targets. At the 6-position, an isopropyl group is attached, contributing to the hydrophobicity and bulkiness of the molecule, which can affect its solubility and membrane permeability. This characteristic is important for the compound's absorption and distribution in biological systems. The 2-position of the pyrimidine ring features a methyl(methylsulfonyl)amino group, which is a secondary amine with a methylsulfonyl group attached to it. This substituent can contribute to the compound's solubility and may also be involved in hydrogen bonding with biological targets, potentially influencing its pharmacological activity. The bromomethyl group at the 5-position is a reactive handle that can be used for further functionalization. Through nucleophilic substitution reactions, this group can be replaced with other functionalities, allowing for the synthesis of a diverse range of derivatives. The compound's complex structure and the presence of multiple functional groups make it a challenging synthetic target. However, its potential applications as a precursor for the synthesis of pharmaceutical agents make it an attractive area of research. The synthesis of 5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine requires a careful selection of reagents and conditions to ensure the desired product is obtained with high purity and yield. This process typically involves a series of organic reactions, including the construction of the pyrimidine ring, the introduction of substituents, and the final installation of the bromomethyl group. In summary, 5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine is a complex organic compound with multiple functional groups, making it a valuable intermediate in the synthesis of pharmaceutical agents. Its unique structure and reactivity make it an interesting subject for further exploration in the field of organic synthesis and medicinal chemistry.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C16H19BrFN3O2S
Assay 99%
Appearance white powder
CAS No.  799842-07-2
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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