(+)-5-Iodo-2′-deoxyuridine CAS:54-42-2

(+)-5-Iodo-2'-deoxyuridine (IUdR) is a halogenated pyrimidine nucleoside analogue that has garnered interest in both virology and oncology for its potential therapeutic applications. The structural modification of adding an iodine atom to the 5-position of 2'-deoxyuridine enhances its ability to interfere with nucleotide metabolism and DNA synthesis. This characteristic makes IUdR an effective tool against rapidly proliferating cells, including those found in tumors. IUdR is primarily employed for its antitumor properties, where it exerts its cytotoxic effects by mimicking thymidine during DNA replication. Consequently, when incorporated into DNA, it disrupts normal transcription and replication processes, ultimately leading to cell cycle arrest and apoptosis. This mechanism is particularly advantageous in treating certain cancers, as it selectively targets malignant cells while sparing normal tissues to some extent. In addition to its use in oncology, IUdR has been investigated for its antiviral activities, particularly against viral infections that rely on host cell machinery for replication. Studies have shown that IUdR can inhibit the replication of viruses like herpes simplex virus (HSV), offering potential avenues for therapeutic development. Moreover, IUdR has been explored in innovative treatment approaches such as radiosensitization in brachytherapy, where localized delivery can enhance the effectiveness of radiation therapy. Its incorporation into tumor DNA allows for more precise targeting and minimization of damage to surrounding healthy tissues. Despite its promise, the clinical application of IUdR is accompanied by challenges, including toxicity profiles and the need for careful dosing regimens. Ongoing research aims to optimize its use and explore combination therapies that could further enhance its efficacy against resistant tumor types. In summary, (+)-5-Iodo-2'-deoxyuridine represents a versatile compound with significant potential in cancer and antiviral therapies.