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6-Methoxy-5-nitroquinazoline CAS:87039-48-3

6-Methoxy-5-nitroquinazoline is a chemical compound belonging to the quinazoline class, known for its electron-rich methoxy group at the 6-position and a nitro group at the 5-position. This structure has piqued interest in the fields of medicinal chemistry and synthetic organic chemistry due to its potential biological activities and synthetic versatility. The presence of electrophilic and nucleophilic groups enhances its reactivity, making it a suitable candidate for various pharmacological studies and a precursor in chemical synthesis, thus contributing to the development of new therapeutic agents.


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Application and Effect:

6-Methoxy-5-nitroquinazoline stands out in medicinal chemistry due to its unique molecular structure and the reactive nature of its functional groups. 1. Medicinal Chemistry: Biological Targets: The nitro and methoxy groups in 6-Methoxy-5-nitroquinazoline suggest potential activity against various biological targets such as enzymes or receptors. The electron-withdrawing nitro group and electron-donating methoxy group may facilitate interactions with biomolecules, influencing key biological pathways. Cancer Research: Due to the structural characteristics that allow for interaction with DNA or proteins, derivatives of 6-Methoxy-5-nitroquinazoline have been explored for their anticancer properties. The compound could interfere with cellular signaling pathways, promoting apoptosis in cancer cells. 2. Drug Development: Structure-Activity Relationship (SAR) Studies: Modifying the quinazoline nucleus or substituents provides insights into the relationship between molecular structure and biological activity, essential for designing more effective and safer drugs. Prodrug Development: The nitro group in particular offers a point for biochemical conversion, allowing for the development of prodrugs that can be activated in specific biological environments, enhancing therapeutic efficacy and reducing side effects. 3. Synthetic Chemistry: Synthetic Routes: The synthesis of 6-Methoxy-5-nitroquinazoline involves nucleophilic aromatic substitution reactions and nitration processes, providing valuable training in advanced synthetic techniques for organic chemists. Intermediates for Complex Molecules: Serving as a precursor, 6-Methoxy-5-nitroquinazoline can be transformed into a range of complex molecules, facilitating the synthesis of diverse pharmacologically active compounds. 4. Biological Evaluation: In Vitro and In Vivo Studies: Early-stage pharmacological evaluations assess the efficacy, toxicity, and metabolic profile of 6-Methoxy-5-nitroquinazoline derivatives. These studies are crucial for determining their suitability as therapeutic agents. In summary, 6-Methoxy-5-nitroquinazoline is a promising compound in the realm of drug discovery, particularly in cancer therapy. Its structural features make it an interesting candidate for developing novel therapeutic agents, with ongoing research needed to explore its full potential and practical applications in medicine. Continued exploration and optimization are vital for translating these early findings into clinically relevant outcomes.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C9H7N3O3
Assay 99%
Appearance white powder
CAS No.  87039-48-3
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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