6-Thioguanine CAS:154-42-7
In medicinal chemistry, 6-thioguanine serves as an important component in chemotherapy regimens, where it acts as a purine analog, disrupting DNA replication and inhibiting the proliferation of cancer cells. Its mechanism of action involves incorporation into DNA and RNA, causing cytotoxicity and cell death in rapidly dividing cells, including cancer cells. Additionally, 6-thioguanine's immunosuppressive effects make it relevant in the treatment of autoimmune disorders, such as rheumatoid arthritis and inflammatory bowel disease. Chemically, the presence of the sulfur substituent in 6-thioguanine modifies its reactivity and pharmacological profile, rendering it an essential agent for targeted therapeutic interventions. The unique structural features of 6-thioguanine provide opportunities for tailored drug design and the development of novel therapeutic strategies. Furthermore, its role as a purine analog underscores its significance in the elucidation of biochemical pathways and drug interactions, contributing to advancements in cancer treatment and immunotherapy. In conclusion, 6-thioguanine holds a crucial place in medicinal chemistry and oncology, offering significant contributions to cancer therapy and immunosuppressive treatments. Its structural and pharmacological attributes make it an indispensable tool in the development of novel drugs and therapeutic approaches for cancer and autoimmune diseases. Continued research and exploration of its potential may lead to further advancements in cancer treatment and the management of various immune-related conditions, ultimately improving patient outcomes and quality of life.
Composition | C5H5N5S |
Assay | 99% |
Appearance | white powder |
CAS No. | 154-42-7 |
Packing | Small and bulk |
Shelf Life | 2 years |
Storage | Store in cool and dry area |
Certification | ISO. |