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6-Thioguanine CAS:154-42-7

6-Thioguanine is an organic compound with the molecular formula C5H5N5S. It is a thiopurine derivative of guanine, a nucleobase found in DNA and RNA. 6-Thioguanine is characterized by the presence of a sulfur atom at the 6th position of the guanine ring. This compound is used as an anticancer medication, particularly in the treatment of acute myeloid leukemia and other hematological malignancies. 6-Thioguanine is also employed in pharmaceutical research for its immunosuppressive properties and potential applications in autoimmune diseases.


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Application and Effect:

In medicinal chemistry, 6-thioguanine serves as an important component in chemotherapy regimens, where it acts as a purine analog, disrupting DNA replication and inhibiting the proliferation of cancer cells. Its mechanism of action involves incorporation into DNA and RNA, causing cytotoxicity and cell death in rapidly dividing cells, including cancer cells. Additionally, 6-thioguanine's immunosuppressive effects make it relevant in the treatment of autoimmune disorders, such as rheumatoid arthritis and inflammatory bowel disease. Chemically, the presence of the sulfur substituent in 6-thioguanine modifies its reactivity and pharmacological profile, rendering it an essential agent for targeted therapeutic interventions. The unique structural features of 6-thioguanine provide opportunities for tailored drug design and the development of novel therapeutic strategies. Furthermore, its role as a purine analog underscores its significance in the elucidation of biochemical pathways and drug interactions, contributing to advancements in cancer treatment and immunotherapy. In conclusion, 6-thioguanine holds a crucial place in medicinal chemistry and oncology, offering significant contributions to cancer therapy and immunosuppressive treatments. Its structural and pharmacological attributes make it an indispensable tool in the development of novel drugs and therapeutic approaches for cancer and autoimmune diseases. Continued research and exploration of its potential may lead to further advancements in cancer treatment and the management of various immune-related conditions, ultimately improving patient outcomes and quality of life.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C5H5N5S
Assay 99%
Appearance white powder
CAS No.  154-42-7
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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