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6-(Trifluoromethoxy)-1H-benzo[d]imidazole CAS:911825-64-4

6-(Trifluoromethoxy)-1H-benzo[d]imidazole is a substituted benzimidazole containing a trifluoromethoxy group on the benzene ring fused to the heterocyclic imidazole. This provides opportunities for functionalization through the labile trifluoromethoxy moiety and nucleophilic aromatic substitutions on the imidazole.


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Application and Effect:

As a versatile building block, this synthon facilitates efficient synthesis of pharmaceuticals, functional materials and agrochemicals. Nucleophilic substitutions on the trifluoromethoxy systematically introduce chemical diversity. Additionally, derivatizations at the imidazole nitrogen furnish analog libraries applicable for biological screening and structure-activity studies. These transformations rapidly generate focused collections for various therapeutic areas. The trifluoromethoxy group also renders this suitable for metal-catalyzed cross-couplings to furnish heterocyclic frameworks. It can serve as a monomer for preparing specialty polymers with properties tuned by the substituent. Furthermore, derivatization provides access to agrochemical prototypes. Therefore, with multiple reactive sites, this versatile intermediate supports synthesis of drugs, advanced materials and crop protection agents through strategic diversification.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C8H5F3N2O
Assay 99%
Appearance white powder
CAS No.  911825-64-4
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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