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9,9-Dimethyl-9H-fluoren-2-yl-boronic acid CAS:333432-28-3

9,9-Dimethyl-9H-fluoren-2-yl-boronic acid, often referred to as DMFBA, is a chemical compound belonging to the class of boronic acids. Its molecular structure features a boronic acid moiety attached to a fluorene scaffold substituted with two methyl groups at the 9-position. This compound holds significant importance in organic synthesis, especially in Suzuki-Miyaura cross-coupling reactions, where it acts as a versatile boronic acid reagent. Additionally, its rigid and sterically hindered structure makes it valuable in ligand design for transition metal-catalyzed reactions and in the development of functional materials.


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Application and Effect:

9,9-Dimethyl-9H-fluoren-2-yl-boronic acid (DMFBA) is a compound with notable structural characteristics and diverse applications across various domains of chemistry. 1. Synthetic Chemistry: Suzuki-Miyaura Cross-Coupling: DMFBA plays a crucial role as a boronic acid reagent in Suzuki-Miyaura cross-coupling reactions, facilitating the synthesis of biaryl compounds. This reaction is widely utilized in organic synthesis for constructing complex molecules, including pharmaceuticals, agrochemicals, and materials. 2. Transition Metal Catalysis: Ligand Design: The fluorene scaffold of DMFBA, combined with its steric hindrance from the methyl groups, makes it an excellent ligand for transition metal-catalyzed reactions. It enhances catalytic activity and selectivity in various transformations, including carbon-carbon and carbon-heteroatom bond formations. 3. Functional Materials: Organic Electronics: DMFBA and its derivatives find applications in organic electronics due to their electron-rich nature and rigid molecular structure. They are employed in the fabrication of organic light-emitting diodes (OLEDs), organic field-effect transistors (OFETs), and other optoelectronic devices. Molecular Recognition: The unique structure of DMFBA enables its use in molecular recognition and sensing applications. By functionalizing DMFBA derivatives with appropriate receptor groups, selective binding to target molecules can be achieved, with potential applications in chemical sensing and detection. 4. Biomedical Applications: Biosensors: DMFBA-based materials have been explored for the development of biosensors capable of detecting biomolecules such as glucose, proteins, and nucleic acids. The boronic acid moiety of DMFBA can selectively bind to certain analytes, enabling the transduction of biological signals into measurable outputs. Therapeutics: DMFBA derivatives have shown potential in medicinal chemistry, particularly in the design of enzyme inhibitors and anticancer agents. Their ability to target specific biomolecules through boronic acid-mediated interactions offers opportunities for the development of novel therapeutics with enhanced efficacy and selectivity. In summary, 9,9-Dimethyl-9H-fluoren-2-yl-boronic acid is a versatile compound with wide-ranging applications in synthetic chemistry, catalysis, materials science, and biomedicine. Its unique structural features and reactivity continue to inspire innovative research and development, driving advancements across various scientific disciplines.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C15H15BO2
Assay 99%
Appearance white powder
CAS No.  333432-28-3
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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