Amlodipine Base CAS:88150-42-9

Amlodipine Base is a widely used antihypertensive agent belonging to the dihydropyridine class of calcium channel blockers. Its primary indication is the treatment of essential hypertension, where it effectively lowers blood pressure by relaxing the arterial walls. The mechanism of action involves the blockade of voltage-gated calcium channels in vascular smooth muscle cells, preventing calcium ions from entering these cells. This leads to decreased intracellular calcium concentrations, resulting in vasodilation, which reduces peripheral vascular resistance and lowers blood pressure. In addition to treating hypertension, Amlodipine is also prescribed for chronic stable angina, where it helps alleviate chest pain by improving blood flow and oxygen delivery to the heart muscle. Patients appreciate its long half-life, which allows for once-daily oral administration, contributing to better medication adherence. Amlodipine is known for its favorable safety profile; common side effects include peripheral edema, dizziness, and flushing. Serious adverse effects are rare but can include hypotension or worsening of heart failure symptoms. It is generally well-tolerated across different populations, including elderly patients and those with comorbidities such as diabetes or coronary artery disease. Clinical studies have demonstrated that Amlodipine not only improves blood pressure control but may also contribute to better cardiovascular outcomes, reducing the risk of stroke, heart attack, and other complications associated with hypertension. With ongoing research exploring its potential applications beyond hypertension and angina, Amlodipine remains an essential component of modern cardiovascular therapy. Its efficacy, safety, and convenience continue to make it a preferred choice for healthcare providers managing patients with cardiovascular diseases.