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Candesartan CAS:139481-59-7 Manufacturer Supplier

Candesartan is an angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively.Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips with no effect on contraction induced by other agents such as norepinephrine, KCl, serotonin, PGF2αor endothelin.


Product Detail

Product Tags

Application and Effect

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

Product Sample

139481-59-7-1
139481-59-7-2

Product Packing:

139481-59-7-3

Additional Information:

Composition C24H20N6O3
Assay 99%
Appearance White powder
CAS No. 139481-59-7
Packing 1KG 25KG
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

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