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Candesartana Cilexetila CAS:145040-37-5

Candesartan Celexetil is an ester analog of the angiotensin II antagonist Candesartan (sc-217825). Antagonism of this receptor prevents the binding of angiotensin II, a potent vasoconstrictor. This has the overall effect of vasodilation and an increased capillary blood volume. Candesartan Celexetil Ester is an inhibitor of AT1.


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Application and Effect

Candesartan cilexetil is a prodrug of the potent, long-acting, and selective angiotensin II type 1 receptor AT1 antagonist, candesartan. It is rapidly hydrolyzed to candesartan during gastrointestinal absorption. After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 AT1 in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure.

Product Sample

145040-37-5-1
145040-37-5-2

Product Packing:

145040-37-5-3

Additional Information:

Composition C33H34N6O6
Assay 99%
Appearance White Powder
CAS No. 145040-37-5
Packing 1KG 25KG
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

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