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Capecitabine CAS:154361-50-9

Capecitabine is an oral chemotherapy medication primarily used to treat various types of cancer, including colorectal and breast cancers. It is a prodrug that is converted into the active form, 5-fluorouracil (5-FU), in the body, exerting its anticancer effects by inhibiting DNA synthesis and disrupting RNA function in rapidly dividing cells. Capecitabine is often utilized in combination with other chemotherapeutic agents to enhance efficacy. Its oral administration offers a convenient alternative to intravenous therapies, improving patient adherence. While generally well-tolerated, capecitabine can cause side effects such as hand-foot syndrome, nausea, and myelosuppression.


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Application and Effect:

Capecitabine is an innovative oral chemotherapeutic agent predominantly indicated for metastatic breast cancer and advanced colorectal cancer, including adjuvant settings following surgical resection. As a prodrug, capecitabine is enzymatically converted into 5-fluorouracil (5-FU) in the liver and tumor tissues, where it becomes biologically active. This conversion takes advantage of increased levels of enzymes like thymidine phosphorylase that are more commonly found in tumor cells, allowing for a more targeted delivery of the cytotoxic agent. The mechanism of action of capecitabine involves the inhibition of thymidylate synthase, leading to the depletion of thymidine triphosphate (dTTP), which is essential for DNA synthesis. By disrupting DNA replication, 5-FU effectively induces apoptosis in malignant cells. One of the significant advantages of capecitabine is its oral formulation, which enhances patient convenience and compliance compared to traditional intravenous chemotherapies. Dosing regimens typically involve administering the drug twice daily for two weeks, followed by a one-week rest period, but can vary based on individual patient factors and treatment goals. Despite its benefits, capecitabine is associated with several adverse effects. The most common include hand-foot syndrome (palmar-plantar erythrodysesthesia), gastrointestinal disturbances such as nausea and diarrhea, and hematologic toxicities like leukopenia and thrombocytopenia. Monitoring and management strategies for these side effects are critical to maintaining quality of life during treatment. In summary, capecitabine represents a significant advancement in cancer therapy, providing an effective, orally administered option for patients with specific malignancies while necessitating careful monitoring for potential side effects.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C15H22FN3O6
Assay 99%
Appearance white powder
CAS No.  154361-50-9
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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