clozapine CAS:5786-21-0

Clozapine is primarily used in the management of schizophrenia, particularly in cases where other antipsychotic medications have proven ineffective. Its unique pharmacological profile, which includes antagonism of dopamine receptors as well as serotonin receptor modulation, makes it effective in reducing positive symptoms (such as hallucinations and delusions) and improving negative symptoms (such as social withdrawal and apathy) associated with schizophrenia. Additionally, clozapine is sometimes used off-label in the treatment of bipolar disorder, particularly in cases with psychotic features or treatment-resistant mania. Despite its efficacy, clozapine is reserved for use in patients who have not responded to other antipsychotic medications due to the risk of serious side effects, including agranulocytosis (a severe decrease in white blood cell count). Regular monitoring of blood cell counts is essential during clozapine therapy to mitigate this risk. Overall, clozapine plays a crucial role in the management of schizophrenia and offers hope to patients who have not found relief with conventional antipsychotic drugs.