dUMP, 2′-Deoxyuridine-5′-monophosphate, disodium salt CAS:42155-08-8

2′-Deoxyuridine-5′-monophosphate (dUMP) is a nucleotide derivative involved in DNA synthesis and repair. It serves as a precursor for dTTP (deoxythymidine triphosphate), which is a necessary building block for DNA replication. dUMP is also a key component in the process of thymidylate biosynthesis, where it is converted into dTMP (deoxythymidine monophosphate) by the enzyme thymidylate synthase. This conversion is essential for maintaining proper nucleotide balance and DNA integrity within cells.

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Application and Effect

DNA Synthesis: dUMP serves as a precursor for deoxythymidine triphosphate (dTTP), which is essential for DNA replication. The conversion of dUMP to dTMP is a critical step in the synthesis of thymidine nucleotides, which are crucial for the accurate replication of genetic material during cell division.

Thymidylate Biosynthesis: dUMP is the substrate for the enzyme thymidylate synthase, which catalyzes the conversion of dUMP to dTMP. This process is important for maintaining proper nucleotide balance in cells and ensuring the fidelity of DNA replication.

Anticancer Drug Target: Thymidylate synthase, the enzyme involved in the conversion of dUMP to dTMP, is a target for certain anticancer drugs. Inhibiting thymidylate synthase can disrupt DNA synthesis and cell proliferation, making it a potential target for chemotherapy.

Research Tool: dUMP is utilized in biochemical and molecular biology research as a substrate to study the mechanisms of DNA synthesis, repair, and nucleotide metabolism. It is also used in enzymatic assays to investigate the activity of thymidylate synthase and related enzymes.

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Composition	C9H14N2NaO8P
Assay	99%
Appearance	White powder
CAS No.	42155-08-8
Packing	Small and bulk
Shelf Life	2 years
Storage	Store in cool and dry area
Certification	ISO.