Ethyl 3-amino-4,4,4-trifluorocrotonate CAS:372-29-2

Ethyl 3-amino-4,4,4-trifluorocrotonate, also known as ethyl trifluorocrotonate amine, is a pale yellow liquid characterized by its unique chemical properties. With a chemical formula C6H8F3NO2, it plays a significant role in various industrial applications, leveraging its distinct characteristics. Properties Ethyl 3-amino-4,4,4-trifluorocrotonate features a structure where a trifluoromethyl group (-CF3) is attached to a crotonate backbone, and one of the hydrogens is replaced by an ethyl group (-C2H5). This structural arrangement influences its physical and chemical traits. It typically presents as a pale yellow liquid with a boiling point around 142°C and a density of approximately 1.33 g/cm³. The compound is sparingly soluble in water but dissolves readily in organic solvents such as ethanol and acetone. Uses Intermediate in Organic Synthesis: One of the primary applications of ethyl 3-amino-4,4,4-trifluorocrotonate is as a versatile intermediate in organic synthesis. It serves as a building block for the production of pharmaceuticals, agrochemicals, and specialty chemicals. Its specific chemical structure allows for the introduction of amino and trifluoromethyl groups into more complex molecules. Chemical Reactions: The compound participates in various chemical reactions, including condensation, esterification, and nucleophilic substitution reactions, which are crucial for synthesizing diverse chemical compounds. Pharmaceutical Industry: Ethyl 3-amino-4,4,4-trifluorocrotonate finds application in pharmaceutical research and development, contributing to the synthesis of active pharmaceutical ingredients (APIs) with specific biological activities. Synthesis Ethyl 3-amino-4,4,4-trifluorocrotonate can be synthesized through several methods. One common approach involves the reaction between ethyl crotonate and 3-amino-4,4,4-trifluorocrotonic acid under controlled conditions. This reaction yields ethyl 3-amino-4,4,4-trifluorocrotonate as the main product, which can be isolated and purified to achieve high yields and purity suitable for industrial applications. In summary, ethyl 3-amino-4,4,4-trifluorocrotonate is a versatile compound essential in organic synthesis and pharmaceutical development. Its unique chemical properties and structural characteristics make it invaluable across various sectors, contributing significantly to the advancement of chemical and pharmaceutical sciences.