Ethyl 4,4-difluoro-3-oxobutyrate CAS:352-24-9

Ethyl 4,4-difluoro-3-oxobutyrate features a structure where a difluoromethyl group (-CF2) is attached to a β-ketoester backbone, and one of the hydrogens is replaced by an ethyl group (-C2H5). This structural configuration influences its physical and chemical characteristics. It typically exists as a colorless liquid with a boiling point around 130°C and a density of approximately 1.27 g/cm³. The compound is sparingly soluble in water but dissolves readily in organic solvents such as ethanol and acetone. Uses Fragrance Industry: Ethyl 4,4-difluoro-3-oxobutyrate is widely used in the fragrance sector due to its fruity aroma. It serves as a valuable ingredient in perfumes, colognes, and other scented products. Chemical Synthesis: The compound acts as a versatile building block in organic synthesis. It participates in various reactions to produce derivatives that are crucial in the pharmaceutical and agrochemical industries. Intermediate: In organic chemistry, ethyl 4,4-difluoro-3-oxobutyrate serves as an intermediate for the synthesis of more complex compounds, contributing to the development of new materials and chemical processes. Synthesis Ethyl 4,4-difluoro-3-oxobutyrate can be synthesized through several methods. One common approach involves the reaction between ethyl acetoacetate and 2,2-difluoroethyl bromide under basic conditions. This reaction leads to the formation of ethyl 4,4-difluoro-3-oxobutyrate as the main product, which can then be purified to obtain high yields and purity. In summary, ethyl 4,4-difluoro-3-oxobutyrate is a versatile compound essential in fragrance creation, chemical synthesis, and industrial applications. Its distinctive properties, including solubility and specific chemical structure, make it valuable across various sectors, contributing significantly to the formulation of diverse consumer and industrial products.