ethyl 4,4,4-trifluoroacetoacetate CAS:372-31-6

Ethyl 4,4,4-trifluoroacetoacetate, also known as ethyl trifluoroacetoacetate, is a colorless liquid characterized by its sharp, fruity odor. With a chemical formula C6H6F3O3, it serves pivotal roles in various industrial applications due to its distinct chemical properties. Properties Ethyl 4,4,4-trifluoroacetoacetate features a structure where a trifluoromethyl group (-CF3) is attached to a β-ketoester backbone, and one of the hydrogens is substituted by an ethyl group (-C2H5). This structural arrangement influences its physical and chemical traits. It typically presents as a colorless liquid with a boiling point around 120°C and a density of approximately 1.35 g/cm³. While sparingly soluble in water, it readily dissolves in organic solvents such as ethanol and acetone. Uses Fragrance Industry: Ethyl 4,4,4-trifluoroacetoacetate is highly prized in the fragrance sector for its sharp, fruity aroma. It is extensively used in perfumes, colognes, and other scented products to impart distinctive olfactory notes. Chemical Synthesis: The compound serves as a versatile intermediate in organic synthesis. It participates in various reactions to produce derivatives crucial for pharmaceuticals, agrochemicals, and specialty chemicals, owing to its unique chemical reactivity. Flavor Enhancer: In addition to its role in fragrances, ethyl 4,4,4-trifluoroacetoacetate is employed in the food industry as a flavor enhancer due to its fruity aroma profile. Synthesis Ethyl 4,4,4-trifluoroacetoacetate can be synthesized through several methods. A common approach involves the reaction between ethyl acetoacetate and trifluoroacetic acid under controlled conditions. This reaction yields ethyl 4,4,4-trifluoroacetoacetate as the main product, which can then be purified to achieve high yields and purity suitable for industrial applications. In summary, ethyl 4,4,4-trifluoroacetoacetate is a versatile compound essential in fragrance creation, chemical synthesis, and various industrial applications. Its distinct properties, including solubility and specific chemical structure, make it indispensable across multiple sectors, contributing significantly to the formulation of diverse consumer and industrial products.