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Fmoc-Arg(Tos)-OH CAS:83792-47-6

Fmoc-Arg(Tos)-OH, or Fmoc-arginine with tosyl (Tos) protection, is a key derivative employed in peptide synthesis. Featuring a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group attached to the arginine molecule, with an additional tosyl group on the guanidine nitrogen, this compound offers enhanced selectivity during peptide chain elongation. Fmoc-Arg(Tos)-OH is notable for its specialized role in peptide chemistry, where the dual protection strategy facilitates controlled manipulation of the guanidine nitrogen’s reactivity.


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Application and Effect:

Fmoc-Arg(Tos)-OH plays a crucial role in peptide synthesis, particularly when precise protection of the guanidine nitrogen in arginine is required. The Fmoc protecting group shields the amino group, ensuring selective reactions during peptide coupling, while the tosyl group on the guanidine nitrogen provides an additional layer of protection. Researchers utilize Fmoc-Arg(Tos)-OH for synthesizing peptides with specific guanidine modifications, influencing their biological activities. The dual protection approach enables controlled manipulation of guanidine reactivity, making this compound valuable in designing peptides for antimicrobial studies, bioconjugation, and medicinal chemistry. The compatibility of Fmoc-Arg(Tos)-OH with standard peptide synthesis methods, including solid-phase peptide synthesis (SPPS), enhances its utility. This compound finds application in constructing peptides for biological assays, drug discovery, and the development of peptide-based materials. Controlled removal of protecting groups allows for the strategic incorporation of arginine with modified guanidine, contributing to the diversity of peptides that can be synthesized. In summary, Fmoc-Arg(Tos)-OH stands as a specialized and versatile tool in peptide chemistry, empowering researchers to explore and modify guanidine reactivity for a range of scientific and therapeutic applications.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C28H30N4O6S
Assay 99%
Appearance white powder
CAS No.  83792-47-6
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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