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Geldanamycin CAS:30562-34-6

Geldanamycin is a naturally occurring antibiotic derived from Streptomyces hygroscopicus. It belongs to the class of benzoquinone ansamycins and exhibits potent anti-cancer properties by inhibiting heat shock protein 90 (Hsp90), a chaperone protein essential for cancer cell survival. Geldanamycin has shown promise in preclinical studies as a potential therapeutic agent against various types of cancers.


Product Detail

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Application and Effect:

Although geldanamycin has demonstrated anti-cancer activity in laboratory studies, its clinical use is limited due to challenges related to toxicity and stability. Research efforts are ongoing to develop derivatives and analogs of geldanamycin with improved pharmacokinetic properties and reduced side effects for potential therapeutic applications. In experimental settings, geldanamycin and its derivatives have been investigated for their ability to inhibit Hsp90 function, leading to the degradation of client proteins involved in cancer cell growth and survival. This mechanism makes geldanamycin a promising candidate for targeted cancer therapy, particularly in cancers dependent on Hsp90-regulated pathways. Clinical trials exploring the efficacy and safety of geldanamycin derivatives in cancer patients are underway to evaluate their potential as anti-cancer agents. These studies aim to assess the drug's therapeutic benefits, optimal dosing regimens, response rates, and any associated adverse effects to determine their clinical utility in oncology practice. Collaboration between researchers, pharmaceutical companies, regulatory agencies, and healthcare providers is essential to advance the development of geldanamycin-based therapies and bring novel anti-cancer treatments to patients in need. Continued investigation into the pharmacological profile and clinical outcomes of geldanamycin derivatives holds promise for improving cancer treatment strategies and outcomes in the future.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C29H40N2O9
Assay 99%
Appearance white powder
CAS No.  30562-34-6
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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