isobutylmagnesium bromide CAS:926-62-5
Isobutylmagnesium bromide (C₄H₉MgBr) is a prominent member of the Grignard reagent family, characterized by an isobutyl group connected to a magnesium atom coordinated with a bromine atom. The structure consists of a branched alkyl chain, which imparts unique reactivity characteristics, making it useful for a variety of applications in organic synthesis. One of the main roles of isobutylmagnesium bromide is as a nucleophile in chemical reactions. It exhibits high reactivity towards electrophilic centers, particularly carbonyl compounds. When isobutylmagnesium bromide reacts with aldehydes or ketones, it undergoes nucleophilic addition, resulting in the formation of secondary or tertiary alcohols, depending on the nature of the carbonyl compound. For instance, reacting isobutylmagnesium bromide with formaldehyde yields a secondary alcohol, while interaction with acetone produces a tertiary alcohol. These alcohols serve as essential intermediates in the synthesis of more complex organic molecules. In addition to carbonyl compounds, isobutylmagnesium bromide can participate in reactions with epoxides and other electrophiles. Its ability to attack different substrates allows for the construction of diverse molecular frameworks, which can be crucial in producing compounds found in natural products and pharmaceutical formulations. Another significant application of isobutylmagnesium bromide is in the synthesis of branched hydrocarbons, which are important in the development of specialty chemicals and performance materials. By reacting this Grignard reagent with various electrophiles, chemists can create longer carbon chains or introduce functional groups that enhance the properties of the final product. However, working with isobutylmagnesium bromide requires caution due to its sensitivity to moisture and air. It must be stored under anhydrous conditions to prevent hydrolysis, which can lead to the release of flammable gases and hazardous conditions. Proper safety measures, including the use of inert atmospheres during reactions, are vital to ensure safe handling. In summary, isobutylmagnesium bromide is a versatile and essential reagent in organic synthesis, known for its ability to form carbon-carbon bonds and generate various functionalized products. Its unique properties allow chemists to construct complex organic molecules, making it invaluable in fields such as pharmaceuticals, agrochemicals, and materials science. Understanding its reactivity and applications enhances synthetic strategies and contributes significantly to advancements in chemical research.
Composition | C4H9BrMg |
Assay | 99% |
Appearance | white powder |
CAS No. | 926-62-5 |
Packing | Small and bulk |
Shelf Life | 2 years |
Storage | Store in cool and dry area |
Certification | ISO. |