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Isobutylmagnesium chloride CAS:5674-02-2

Isobutylmagnesium chloride (C4H9MgCl) is an organometallic compound classified as a Grignard reagent, featuring an isobutyl group linked to a magnesium atom that is coordinated with chlorine. This reagent is particularly valued for its nucleophilic characteristics, allowing it to react readily with various electrophiles. Isobutylmagnesium chloride is widely utilized in organic synthesis for forming carbon-carbon bonds and generating alcohols from carbonyl compounds. Its applications extend across the fields of pharmaceuticals, agrochemicals, and materials science, making it an important tool in modern synthetic chemistry.


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Application and Effect:

Isobutylmagnesium chloride (C₄H₉MgCl) is a significant member of the Grignard reagents, characterized by an isobutyl group that is attached to a magnesium atom coordinated with a chlorine atom. The molecular structure features a branched alkyl chain that imparts unique reactivity properties, thus making isobutylmagnesium chloride an essential reagent in organic synthesis. As a powerful nucleophile, isobutylmagnesium chloride reacts vigorously with a wide variety of electrophiles. One of its primary applications is in the nucleophilic addition to carbonyl compounds, including aldehydes and ketones. When this Grignard reagent interacts with these electrophiles, it forms secondary or tertiary alcohols, depending on the nature of the carbonyl compound used. For example, when isobutylmagnesium chloride is added to formaldehyde, it yields a secondary alcohol, while the reaction with acetone produces a tertiary alcohol. These resultant alcohols are crucial intermediates in the synthesis of more complex organic molecules, which can be further modified to yield numerous derivatives. In addition to its reactivity with carbonyls, isobutylmagnesium chloride can also engage in reactions with epoxides and other electrophiles. Its ability to attack various substrates allows chemists to construct diverse molecular architectures, which are vital for producing compounds found in natural products, pharmaceuticals, and specialty chemicals. Another notable aspect of isobutylmagnesium chloride is its application in the synthesis of branched hydrocarbons, which are important in creating high-performance materials and fine chemicals. By reacting this Grignard reagent with other electrophiles, chemists can effectively elongate carbon chains or introduce new functional groups that can enhance the properties of the final product. However, caution is necessary when handling isobutylmagnesium chloride due to its sensitivity to moisture and air. It must be stored and handled under strictly anhydrous conditions to avoid hydrolysis, which could generate flammable gases and hazardous situations. Using inert atmospheres during reactions is crucial for ensuring safe handling and effective use. In conclusion, isobutylmagnesium chloride is a versatile and indispensable reagent in organic synthesis, known for its ability to form carbon-carbon bonds and produce a range of functionalized products. Its unique properties enable chemists to construct intricate organic molecules, making it invaluable across multiple fields such as pharmaceuticals, agrochemicals, and materials science. An understanding of its reactivity and applications is essential for enhancing synthetic strategies and advancing chemical research.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C4H9ClMg
Assay 99%
Appearance white powder
CAS No.  5674-02-2
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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