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Linaclotide CAS:851199-59-2

Linaclotide is a guanylate cyclase-C agonist indicated for the treatment of chronic constipation and irritable bowel syndrome with constipation in adults. It works locally in the gastrointestinal tract to increase fluid secretion and accelerate intestinal transit, alleviating symptoms associated with these conditions.


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Application and Effect:

Linaclotide is utilized for the management of chronic constipation and irritable bowel syndrome with constipation, both of which can significantly impact a patient's quality of life. The medication functions by binding to and activating guanylate cyclase-C receptors in the intestinal epithelium, leading to increased cyclic guanosine monophosphate (cGMP) production. This results in enhanced fluid secretion into the gut lumen and accelerated transit of stool through the intestines. In the context of chronic constipation, linaclotide offers a targeted approach to alleviate symptoms such as infrequent bowel movements, straining during defecation, and a sense of incomplete evacuation. By promoting intestinal motility and facilitating smoother passage of stool, linaclotide helps address underlying factors contributing to chronic constipation and provides relief to affected individuals. For patients with irritable bowel syndrome with constipation (IBS-C), linaclotide represents an important therapeutic option for managing symptoms such as abdominal discomfort, bloating, and altered bowel habits. By enhancing intestinal transit and reducing visceral hypersensitivity, linaclotide may help improve overall bowel function and alleviate the severity of symptoms associated with IBS-C. The recommended dosage of linaclotide is administered orally once daily, typically on an empty stomach at least 30 minutes before the first meal of the day. Adverse effects may include diarrhea, abdominal pain, or flatulence, although these are generally mild and transient in nature. Patient education regarding proper administration and potential side effects is essential for optimizing treatment outcomes and ensuring adherence to the prescribed regimen. Linaclotide has demonstrated efficacy in clinical trials and real-world practice, offering a well-tolerated and effective option for individuals experiencing chronic constipation or IBS-C. Its mechanism of action and localized effects in the gastrointestinal tract make it a valuable addition to the armamentarium of treatments available for these common digestive disorders. In summary, linaclotide plays a crucial role in addressing chronic constipation and irritable bowel syndrome with constipation, providing targeted relief by enhancing intestinal fluid secretion and transit. Close collaboration between healthcare providers and patients is essential for integrating linaclotide into the overall management plan for these conditions, tailoring treatment approaches to individual patient needs and optimizing the balance between symptom control and potential adverse effects.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C59H79N15O21S6
Assay 99%
Appearance white powder
CAS No.  851199-59-2
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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