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LL-37 CAS:154947-66-7

LL-37, also known as Cathelicidin antimicrobial peptide, is a naturally occurring peptide in humans with significant antimicrobial properties. It is part of the innate immune system and exhibits broad-spectrum activity against bacteria, fungi, and viruses. LL-37 plays a crucial role in immune defense, wound healing, and inflammation modulation.


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Application and Effect:

LL-37, a peptide derived from the human cathelicidin protein, serves multiple vital functions in innate immunity and beyond. Its antimicrobial properties are well-documented, making it effective against a wide range of pathogens, including bacteria like Staphylococcus aureus and Escherichia coli, fungi such as Candida albicans, and even certain viruses. This versatility arises from LL-37's ability to disrupt microbial membranes and interfere with intracellular processes, thereby preventing microbial proliferation. Moreover, LL-37 exhibits immunomodulatory effects, influencing immune cell recruitment, activation, and cytokine production. These functions are crucial for regulating inflammation and promoting wound healing. In inflammatory conditions, LL-37 can either amplify or suppress immune responses, depending on the context, making it a pivotal player in maintaining immune homeostasis. Beyond its direct antimicrobial and immunomodulatory roles, LL-37 has garnered interest in therapeutic applications. Research suggests potential uses in combating antibiotic-resistant infections, enhancing wound healing in chronic wounds, and even as a therapeutic agent in dermatological conditions like psoriasis. Its ability to promote tissue repair and reduce inflammation underscores its potential in diverse medical fields. In clinical settings, LL-37's application can vary from topical formulations for wound care to systemic treatments in combating infectious diseases. Researchers are also exploring synthetic analogs and derivatives to optimize its therapeutic efficacy and safety profile. In summary, LL-37 represents a multifaceted peptide with significant implications for both basic research and clinical practice. Its innate antimicrobial prowess, coupled with immunomodulatory functions, positions it uniquely in the landscape of therapeutic peptides. Continued research into its mechanisms and applications promises to unveil further potential uses in treating infectious diseases, chronic inflammatory conditions, and beyond, highlighting LL-37 as a compelling target for future biomedical innovations.

Product Sample:

Amino acid powder1
Amino acid powder2

Product Packing:

Amino acid powder3
Amino acid powder4
Amino acid powder5
Amino acid powder6

Additional Information:

Composition C205H340N60O53
Assay 99%
Appearance white powder
CAS No.  154947-66-7
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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