methyl 1-(3-bromophenyl)-3,3-dimethoxycyclobutane-1-carboxylate CAS:2322886-10-0

As a versatile synthetic building block, this compound facilitates efficient synthesis of pharmaceuticals, materials and agrochemicals. Nucleophilic substitutions on the aryl bromide systematically introduce diversity for biological evaluation and structure-activity studies. Meanwhile, ester hydrolysis furnishes varied acids and alcohols. These transformations enable generation of focused compound libraries in a rapid, systematic manner. Additionally, the rigid cyclobutane supports metal-catalyzed couplings to generate heterocyclic fragments. It can also serve as a monomer to produce specialty polymers with controlled solubility, stability and mechanical behavior. Derivatizations further allow construction of agrochemical prototypes. Overall, owing to its multiple functional sites, this synthon enables versatile synthesis of drugs, materials and agricultural chemicals through diverse manipulations.