Methyl 2-iodobenzoate CAS:610-97-9

Methyl 2-iodobenzoate (C9H9IO2) is an organic compound classified as an aromatic ester, featuring a benzoate moiety substituted by an iodine atom at the 2-position of the benzene ring and a methyl ester group (-COOCH₃). Its unique structure endows it with distinctive properties that are highly beneficial in synthetic organic chemistry. One of the most significant features of methyl 2-iodobenzoate is its reactivity due to the presence of the iodine substituent. The iodine atom acts as a good leaving group in nucleophilic substitution reactions, making it an excellent candidate for various transformations. For instance, it can undergo nucleophilic substitutions to form a range of derivatives, enabling the synthesis of more complex organic molecules. This property is particularly useful in the preparation of pharmaceuticals and biologically active compounds, where precise modifications of molecular structures are essential. In addition to its use in nucleophilic substitution, methyl 2-iodobenzoate is also employed in cross-coupling reactions, such as the Suzuki-Miyaura and Sonogashira reactions. In these processes, the compound acts as an electrophile, allowing for the construction of carbon-carbon bonds that are vital in building intricate molecular architectures used in drug development and material science. Furthermore, esters like methyl 2-iodobenzoate often serve as precursors in the synthesis of functional materials, including polymers and advanced coatings, due to their favorable reactivity. They can contribute to developing organic electronic materials and specialty chemicals. Overall, methyl 2-iodobenzoate is a versatile compound with significant applications in organic synthesis, pharmaceutical research, and materials science. Its ability to facilitate diverse chemical transformations underscores its importance in advancing various fields within chemistry.