N-(5-bromo-[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide CAS:1256958-83-4
The synthesis of N-(5-bromo-[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide typically involves intricate synthetic routes employing commercially available starting materials. Common methods include the condensation of appropriate thiazolo[4,5-b]pyridine derivatives with benzoyl halides, followed by bromination to introduce the desired bromo substituent. Analytical techniques such as NMR, IR, and mass spectrometry are utilized to confirm the compound's identity and purity. Molecularly, N-(5-bromo-[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide exhibits planarity attributed to conjugation within the thiazolo[4,5-b]pyridine ring system. The bromo substituent adds to the compound's chemical diversity, potentially influencing its reactivity and pharmacological properties. The benzamide moiety introduces polarity and offers opportunities for hydrogen bonding interactions, impacting the compound's solubility and affinity for biological targets. Pharmacological Significance and Potential Applications The structural framework of N-(5-bromo-[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide positions it as a promising candidate for pharmaceutical exploration. Thiazolo[4,5-b]pyridine derivatives are recognized for their versatile biological activities, encompassing antimicrobial, antiviral, and antiproliferative effects. The presence of the bromo substituent may further enhance the compound's pharmacological profile, potentially improving its selectivity and potency against specific molecular targets. The benzamide functionality in N-(5-bromo-[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide can facilitate interactions with relevant biomolecules through hydrogen bonding or hydrophobic contacts. This offers avenues for the development of novel therapeutic agents targeting various disease indications, including infectious diseases, cancer, and inflammatory disorders. In summary, N-(5-bromo-[1,3]thiazolo[4,5-b]pyridin-2-yl)benzamide emerges as a compelling molecular entity with promising pharmaceutical implications. Further investigations into its synthesis, structure-activity relationships, and pharmacological applications are warranted to harness its full therapeutic potential across diverse medical domains.
Composition | C13H8BrN3OS |
Assay | 99% |
Appearance | white powder |
CAS No. | 1256958-83-4 |
Packing | Small and bulk |
Shelf Life | 2 years |
Storage | Store in cool and dry area |
Certification | ISO. |