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Oxydiethylene bis(chloroformate) CAS:106-75-2

Oxydiethylene bis(chloroformate) is a symmetrical organic compound featuring two chloroformate functional groups attached to an oxydiethylene backbone. This diacyl chloride serves as a potent acylating agent in organic synthesis, facilitating the formation of carbamates and esters through nucleophilic substitution reactions with amines and alcohols. Its unique structure enhances its reactivity, making it invaluable in the fields of pharmaceuticals, agrochemicals, and polymer chemistry. The versatility of oxydiethylene bis(chloroformate) allows for the modification of various nucleophiles, resulting in diverse chemical products. Understanding its properties and handling precautions is essential for chemists utilizing this important reagent in synthetic processes.


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Application and Effect:

Oxydiethylene bis(chloroformate) (C6H10Cl2O4) is a significant reagent in organic synthesis, characterized by the presence of two chloroformate groups linked by an oxydiethylene chain (–O–CH2–CH2–O–). This structural feature imparts unique reactivity and versatility, rendering it useful in a variety of chemical transformations. As an acylating agent, oxydiethylene bis(chloroformate) readily reacts with nucleophiles such as alcohols and amines, enabling the synthesis of a wide range of derivatives, including carbamates and esters. One of the primary applications of oxydiethylene bis(chloroformate) is in the preparation of carbamates, which are crucial intermediates in pharmaceutical development and agrochemical formulations. When reacted with amines, this compound efficiently forms carbamate linkages that can exhibit significant biological activity. The ability to modify the oxydiethylene moiety allows chemists to tailor the physicochemical properties of the resulting carbamates, enhancing their solubility and bioavailability. In addition to carbamate synthesis, oxydiethylene bis(chloroformate) is also utilized to produce esters from alcohols. These esters find applications as solvents, plasticizers, and additives in various industrial processes. The presence of two chloroformate groups increases the reactivity of the compound, allowing for efficient acylation under mild reaction conditions. Furthermore, oxydiethylene bis(chloroformate) can serve as a protecting group for alcohols and amines in multi-step syntheses. By temporarily masking reactive sites, it provides greater control over reaction pathways, minimizing side reactions and enhancing overall yields. Once the desired transformations are complete, the protection can be removed under mild conditions, restoring the original functionality. However, handling oxydiethylene bis(chloroformate) requires caution due to its corrosive nature and potential health hazards. Appropriate safety measures, including the use of personal protective equipment and conducting work in well-ventilated areas, are essential. In summary, oxydiethylene bis(chloroformate) is a valuable reagent in organic synthesis, enabling the efficient production of carbamates, esters, and other derivatives. Its unique structure and high reactivity make it an indispensable tool for chemists engaged in the development of complex organic compounds across pharmaceuticals, agrochemicals, and materials science.

Product Sample:

L-Arginine1
L-Arginine2

Product Packing:

L-Arginin3

Additional Information:

Composition C6H8Cl2O5
Assay 99%
Appearance white powder
CAS No.  106-75-2
Packing Small and bulk
Shelf Life 2 years
Storage Store in cool and dry area
Certification ISO.

 


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