P21 CAS:128-37-0

P21, or cyclin-dependent kinase inhibitor 1A, is instrumental in maintaining cellular integrity and genomic stability. Upon sensing DNA damage or other stress signals, P21 inhibits cyclin-dependent kinases, halting cell cycle progression and allowing time for repair mechanisms to operate. This function is crucial for preventing the propagation of damaged DNA, thereby reducing the risk of mutations and cancer development. Additionally, P21's regulatory role extends beyond cell cycle arrest; it influences cellular senescence, differentiation, and apoptosis, contributing significantly to various physiological processes and disease pathways. Research into P21 continues to uncover its potential therapeutic applications in cancer treatment and age-related disorders.